The invention discloses an intelligent partition isolation dust reduction system and device for a fully mechanized coal mining face. In the coal mining process, the dust reduction device is mainly arranged on the dust removal fan, the shearer body and the dust removal fan body. The transparent high-strength material dust blocking plate in front of the column achieves the purpose of dustproof. A dust removal fan is arranged at the front and rear of the shearer. The dust concentration sensor transmits the detected concentration change to the central processing unit, and then the signal is transmitted to the dust removal fan motor speed frequency conversion device and the spray pump plunger reciprocating frequency conversion device to realize the change of suction air volume and spray pressure. Dust spreads continuously on the working face. In order to prevent dust from spreading to one side of the sidewalk, a transparent high-strength material dust blocking plate is arranged between the hydraulic support column and the cable trough. Nozzles and dust removal brushes are installed below the dust blocking plate to remove dust stuck on it. The shearer position transmitter is arranged at the shearer body. When the shearer moves, the shearer position receiver installed on the hydraulic support receives the signal. Under the automatic control of the central processing unit, the nozzles and dust brushes at several frames on the upwind side and all hydraulic supports on the downwind side of the shearer start to work. Through the combination of spray dust reduction, dust collection of dust collector and dust blocking plate, an intelligent partition isolation comprehensive dust reduction system for the cutting dust of shearer is formed in the fully mechanized working face.