Chinese herbal medicine is the precious wealth of Chinese medicine, the patron saint of our health, and a good teaching material for children to experience the breadth and depth of Chinese medicine from an early age. This topic is based on the Unity3D platform to develop a three-dimensional popular science puzzle game, mainly for children's science knowledge of Chinese herbal medicine, entertaining, so that children in the game to understand common Chinese herbal medicine, acquisition of knowledge of Chinese herbal medicine. Using the Unity3D engine to effectively integrate the knowledge of traditional Chinese medicine with simple and interesting game elements, and develop a popular science interactive game with educational guidance nature, which can enhance the interest of the knowledge dissemination process and enable children to master common traditional Chinese medicine knowledge in a relaxed and happy atmosphere. According to the learning characteristics of children's intuitive image thinking, this topic uses pictures and videos to select common Chinese herbal medicine in life to guide children to perceive and observe, so that children can understand the magic of Chinese herbal medicine in the process of exploration, discovery and experience, and further feel the relationship between Chinese herbal medicine and people's healthy life, germinate children's interest in traditional Chinese medicine culture, and enhance children's national pride.