This work is based on the Unreal Engine4 game engine. It is a first-person exploration popular science interactive game based on puzzle solving and popular science. The game is presented in the form of 3D real style combined with 2D animation. The story through memories and old Chinese grandpa life past as the main line. In order to create an immersive experience for players, the game builds a game scene and game atmosphere that truly restore the background of the story. Players have great freedom within the scene and can explore the scene. Through the interactive way of triggering memory points and clue collection, various memories with grandpa are drawn out, and the popular science of traditional Chinese medicine cultural knowledge is included in the memories. Through this game, it is intended to promote Chinese medicine in the history of our country, popularize Chinese medicine in life, enhance users' national self-confidence, and contribute to the inheritance and development of Chinese medicine today.