Based on the requirements of intelligent agriculture for intelligent, high-efficiency, low-quantity, accurate and safe pesticide application technology, this work realizes intelligent, high-efficiency, low-quantity and accurate pesticide application through the development of online drug mixing system, integrated variable drug application technology and innovative design of embedded double-plate fan-shaped electrostatic atomization nozzle. The pesticide utilization rate can reach 65%. Compared with traditional drug application technology, it saves 30% of pesticide and 50% of water. In this work, the relationship between different concentrations of liquid medicine and conductivity is obtained through experiments. The domestic leading control LK3U-14 PLC is used as the control unit to design the on-line chemical mixing electrical monitoring system (composed of conductivity sensor, pressure sensor and flow sensor), water and chemical delivery and mixing system (composed of water tank, medicine box, jet device and static chemical mixer) and electrical control system (composed of peristaltic pump and water pump). The developed mixing device has a mixing error value of less than 5%, which meets the requirements of plant protection operations. At the same time, mixing and applying can avoid pollution caused by multiple pairs of liquid medicine. At the same time, this work also innovatively designs an embedded double flat plate fan-shaped electrostatic atomization nozzle, which can effectively reduce the drift of liquid medicine droplets, increase the adhesion rate of liquid medicine, and significantly improve the utilization rate of pesticides. Through the integration of rotational speed sensors, ranging sensors and other real-time monitoring of plant protection machinery operation speed, plant position information, adjust spray flow, realize precision operation, reduce pesticide waste.